Lions Mane Mushroom & Cancer

Lion's mane mushroom (Hericium erinaceus) has shown therapeutic potential against cancers of gastric, liver, colon, leukemia, melanoma, skin cancer, lung, breast and prostate cancer [1,2].

Hericium erinaceus against three gastrointestinal cancers such as liver, colorectal and gastric cancers and compounds have the potential for development into anticancer agents for the treatment of gastrointestinal cancer used alone and/or in combination with clinical used chemotherapeutic drugs[3].

A study indicates that H. erinaceus mushrooms may have therapeutic potential against human leukemia by inducing apoptosis (programmed cell death) in U937 human monocytic leukemia cells[4].

Aromatic compounds in lions mane mushroom show anticancer activities[5]. 


Reference List
  1. Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget 2018;9(49):29259-74. PMID 30018750
  2. Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. Journal of agricultural and food chemistry 2013;61(20):4898-904. PMID 23668749
  3. Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. Journal of ethnopharmacology 2014;153(2):521-30. PMID 24631140
  4. Kim SP, Kang MY, Choi YH, Kim JH, Nam SH, Friedman M. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food & function 2011;2(6):348-56. PMID 21779573
  5. Li W, Zhou W, Kim EJ, Shim SH, Kang HK, Kim YH. Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities. Food chemistry 2015;170:336-42. PMID 25306354