Lion's Mane Mushroom & Depression

Hericium erinaceus mushroom and mycelium both have promising compounds that may help treat depression. Some related studies are:
  1. Preclinical studies have shown that there can be improvements in depression with Hericium erinaceus mycelium enriched with erinacines[1].
  2. Another study has shown Hericium erinaceus reduces Depressive Behaviors by Promoting hippocampal neurogenesis in the Adult Mouse Brain[2].
  3. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. HE intake has the possibility to reduce depression by 4 weeks NGF-enhancing action[3].
  4. An article that critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities[4].
  5. Erinacine a-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice[5].

Reference List

  1. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behavioural neurology 2018;2018:5802634. PMID 29951133
  2. Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. Journal of medicinal food 2018;21(2):174-80. PMID 29091526
  3. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical research (Tokyo, Japan) 2010;31(4):231-7. PMID 20834180
  4. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. International journal of molecular sciences 2019;21(1):E163. PMID 31881712
  5. Chiu CH, Chyau CC, Chen CC, Lee LY, Chen WP, Liu JL, Lin WH, Mong MC. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. International journal of molecular sciences 2018;19(2):E341. PMID 29364170